In general, no. Cartridge grids by themselves do not filter low enough microns to trap calcium. However, you can add a small amount of diatomacious earth to temporarily aide filtration, which may be enough to remove some degree of calcium hardness ...
In general, no. Sand doesn't filter small enough microns to capture calcium. You may consider using crushed glass media, which will filter down to 5 microns. This should be sufficient to remove calcium hardness using Cal Treat.